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This remarkable anti-aging serum works in eight ways to promote a youthful, healthy complexion. DefenAge 8-in-1 BioSerum contains ingredients that are clinically proven to rejuvenate and restore vitality to skin. Niacinamide soothes and promotes microcirculation, while a select blend of peptides and proprietary Defensins smooth fine lines, brightens hyperpigmentation and firms skin for an improved facial contour.
An amino-acid based, synthetic form of the body’s naturally produced alpha-defensins, that work to facilitate the production of new skin.
Water (Aqua) Cyclopentasiloxane Glycerin Niacinamide Sinorhizobium Meliloti Ferment FiltrateDimethicone Polysorbate 20 Dimethicone/Vinyl Dimethicone Crosspolymer Lauryl PEG-9 Polydimethylsiloxyethyl DimethiconeAmmonium Acryloyldimethyltaurate/VP Copolymer Phospholipids Alpha-Defensin 5 Beta-Defensin 3 Palmitoyl Tripeptide-38 Sodium Hyaluronate Arabidopsis Thaliana ExtractSea Whip Extract Ergothioneine Helianthus Annuus (Sunflower) Seed Oil Rosmarinus Offinalis (Rosemary) Leaf ExtractTocopheryl Acetate Ubiquinone Leuconostoc/Radish Root Ferment Filtrate Albumin L-Alanyl-L-GlutamineCaprylic/Capric Triglyceride Cetyl Hydroxyethylcellulose Lecithin Hydroxypropyl Cyclodextrin Phytic Acid Phenoxyethanol Caprylyl Glycol Ethylhexylglycerin Hexylene Glycol Sodium Chloride
Daily: AM | PM
While skin is still moist, lightly massage with fingertips first around eyes, then over entire face, neck and décolleté. Follow with sunscreen. Effective for all skin types, ages, and ethnicities. Apply after the 24/7 Barrier Balance Cream.
Note: To dispense, twist the top of the container to unlock the pump. Press pump to dispense product. For visual: please see video on product page.
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The DefenAge 8 in 1 BioSerum is the last skincare product applied to the skin. In the morning, you can apply sunscreen and makeup after the DefenAge 8 in 1 BioSerum.
| Item Id | S36651 |
| Size | 1.5 fl oz |
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Inspired by the recent discovery of the skin's regeneration process, the scientists at DefenAge have identified how to unlock the key to youth with powerful, synthetically produced messenger peptides called Age-Repair Defensins. DefenAge skin care is founded on a three product anti-aging system that use Age-Repair Defensins to rejuvenate skin naturally and effectively. DefenAge anti-aging formulations act with your body's stem cells to trigger the creation of new skin, improving pore size, wrinkles, oiliness, skin tone and more.
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175 Reviews
AWL
Verified Purchase
This serum was recommended to me a few years ago by my skincare person. I use it after cleansing, and before I apply my other products. Layering skincare products helps with an anti-aging skincare program (I'm 73 and this matters to me! People stop me everywhere to ask me what I use on my skin.) This gel serum quickly sinks in and is a beautiful nutrient to apply before Retin A, a glycolic acid product, or a moisturizer.
0 people found this helpful
LovelySkin Customer
Verified Purchase
At first I wasn’t sure if it was this or another product that was making my skin look so good. I t was definitely this. It brightens and shrinks pores. I only use at bedtime to make it last.
0 people found this helpful
LovelySkin Customer
Verified Purchase
I don’t understand the hype. One pump does not go far and isn’t enough to cover my face. This product has done nothing for me after three months of use.
0 people found this helpful
Hdhd
Verified Purchase
This serum feels nice.. I am honestly not sure if it is doing anything ..I will update when I finish the bottle
0 people found this helpful
GigiM
Verified Purchase
I switched to DefenAge 8 in 1 serum from others I have used . I’ve noticed this one has more noticeable results such as more significant decrease in wrinkles/fine lines, plump and smooth skin, better hydration, more brightness. I’m 41 and people think I’m 25. I still use products from other brands. This seems to do the trick all together, but this serum is a 10+! Noticed it makes my nails grow to by accident.
0 people found this helpful
LovelySkin Customer
Verified Purchase
My mature skin is very dry. I use this product with Defenage 24/7 Barrier Balance cream to deeply moisturize my face, neck and décolleté. This lovely serum is light with a velvety texture. After using, my skin feels moist, plumped and soft.
0 people found this helpful
gocammygirl
Verified Purchase
I was introduced to this product line at the salon where I get skin treatments done. I decided to try it and am pleased with the results. I ran into a friend I hadn't seen in over a year and she asked me what I was doing to my skin as it looks amazing. I should note that I'm using this in conjunction with the Barrier Balance Cream. Give them a try. You'll be pleased with the results.
0 people found this helpful
LovelySkin Customer
Verified Purchase
I use the DefenAge serum with its face cream. I switched to DefenAge 2 years ago. My skin looks much better than before. I no longer have dry skin. I use both in the morning and evening. Just simple routine that does all the work without any additional products. Highly recommended,
0 people found this helpful
ProductLove
Verified Purchase
I combine this serum as a first step with all my other actives and it seems to make the other actives penetrate better. My pores are invisible and fine lines and firmness have improved. Love love love this serum.
0 people found this helpful
LovelySkin Customer
Verified Purchase
I struggle with acne prone reactive skin. I tried a sample of the 8 in 1 serum and saw immediate improvement in my skin texture so quickly purchased the full size.
0 people found this helpful
LovelySkin Customer
Verified Purchase
It’s a nice evening serum. I do see better skin as a result on nights that I use it. It’s not oily and looks pretty on the skin.
0 people found this helpful
LovelySkin Customer
Verified Purchase
This serum is supposed to be used at the same time as the Balance Cream. I have always purchased only the serum. Using it alone has given me immediate and dramatic results. Immediate has been achieving brighter, healthier and even skin after only two days of starting to use the serum. By dramatic I mean erasing hyperpigmentation spots from my cheeks, nose and giving me an overall look as if I was 25 years old (while being 38 to 43 years old). It’s one of only two products in the whole world that repair my facial and neck skin so well that I don’t feel the need to use any makeup at all. My pores are smaller, seasonal redness is gone and my face is plumped. The best feature of this serum has been the restoration of my eye area. I don’t have the “sunken eyes” look anymore, that is priceless. Not even the most expensive eye creams have healed this part of my face as this serum. Also, I have to say that not even the eye product sold by DefenAge has been as restorative and faster as the 8 in 1 serum. I recommend it to everyone.
1 person found this helpful
YSS
Verified Purchase
It seems to work well at keeping. my aging 52 yr old skin healthy and glowing. I use it in concert with my Skinceutical C regimen and it has been a keeper!
0 people found this helpful
Jennifergirl625
Verified Purchase
I started using this every morning and at night. After about two weeks I could tell a difference in my skin. Especially the poor size. My skin seemed smoother and the pores tighter. I went out and got two compliments on my skin in one night and the only thing different I can think of that I’ve been doing is using this serum. I say try it!
0 people found this helpful
LovelySkin Customer
Verified Purchase
I’ve been using this product for sometime. Even my dermatologist has committed on how good my 74 year old skin looks
0 people found this helpful
LovelySkin Customer
Verified Purchase
I have been using this for at least a year. My lines have really soften. People can't believe I am 66 years young. You too will love it.
0 people found this helpful
AnntieMae
Verified Purchase
Best product ever! I have tried others and broke out in a rash.
0 people found this helpful
Jlvan
Verified Purchase
Love love this product. Been using for over a year and my skin has never looked better!!
0 people found this helpful
Gingersmom
Verified Purchase
I’ve been using this for years. Recommends for me by my dermatologist. I use this religiously morning and night. My skin is supple and I’ve been told my skin looks great even without makeup and I’m in my 60’s. A must have.
0 people found this helpful
Vuitton24
Verified Purchase
I’m mid 30s with good skin, and saw no results after diligent use of this product. Hydration was balanced but that’s about it. Perhaps try when skin concerns or a mature age merit such a product.
0 people found this helpful
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20% Off Most Brands During Our Spring Renewal Sale + $27 SkinMedica Gift! 
