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Combat the signs of aging while brightening your complexion and controlling acne with iS CLINICAL Active Serum. See a difference in your skin’s texture and tone with regular use of this astonishing facial serum. This product penetrates into the deep layers of your skin for unrivaled results at a cellular level.
An effective and lightweight treatment, iS CLINICAL Active Serum treats multiple skin problems. This anti-aging serum contains acids and botanical extracts to help correct aggravated skin while it calms irritation. With daily use, you’ll notice this advanced skin care product brighten your complexion, smooth skin texture, fight breakouts, lighten dark spots and reduce the appearance of fine lines and wrinkles.
A hydroquinone derivative from the leaves of the bearberry shrub, cranberry, blueberry, some mushrooms and pears that has melanin-inhibiting properties.
Polyporus Umbellatus (Mushroom) ExtractAn extract of mushroom that can help correct discoloration.
Salix Alba (Willow) Bark ExtractAn extract from willow bark that contains anti-inflammatory benefits for the skin.
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iS Clinical is dedicated to providing superior quality skin care products that supercharge your anti-aging skin care routine. From nourishing cleansers to intensive moisturizers and advanced sun protection, every iS Clinical product is designed to restore your skin to its healthiest state. Backed by independent clinical studies, these medical-grade skin care products are cruelty-free, hypoallergenic and made in the USA.
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354 Reviews
LovelySkin Customer
Verified Purchase
I wanted to love this product, but it literally burned my skin!
0 people found this helpful
TWood
Verified Purchase
I use this with the pro heal serum. I think this combination is amazing. I see a big difference in my skin after a few weeks. This is worth it and way easier on the pocketbook than other brands.
0 people found this helpful
MAJ
Verified Purchase
Skincare product junky here. I’ve had this serum on my list to try for years. Finally tried it at the age of 51. It’s rare I put something on my face and feel like I see a difference on day one but the serum did that for me. Everyone is different, but my mature skin loves this.
0 people found this helpful
Supernova3
Verified Purchase
iS Clinical Active Serum is a powerful, multitasking product that smooths, brightens, and clears skin. It absorbs quickly, feels refreshing, and delivers visible results in weeks. A must-try for radiant, healthy skin!
0 people found this helpful
Vuitton24
Verified Purchase
I had been using a competing AHA clearing serum with little results, until changing to this tingly sensational serum that keeps breakouts at bay, controls oil, and infuses skin depth botanicals. Lovely product with great effectiveness that I incorporate every other night.
0 people found this helpful
MissG
Verified Purchase
I love this product! It always helps with my breakouts. I love the tingly sensation! Let’s me know it’s working!
0 people found this helpful
LovelySkin Customer
Verified Purchase
I tried this serum first as a sample I received. It helped to heal itchy burning red spots I got after blue light therapy. I have now purchased my 2nd bottle. Very few drops mixed with hydrologic serum and put it all over my face. And if spots are being more severe I put it straight on. I use this and the pro-heal serum which is made by this company. My face texture has gotten more smooth and looks better. I will be continuing to use these products. Highly recommend this product.
0 people found this helpful
Diana445
Verified Purchase
I’ve been using this serum for almost 10 years and will never go without it! It’s the one consistent product in my skincare routine that keeps my pores small and breakouts minimal. While the cost might seem like a lot, the bottle lasts at least 6 months if you use the product correctly! I typically use it in my nighttime routine and will put about 4-5 drops in my palm then use my finger to tap it around my face and neck. If you’re going to implement any product into your routine I highly suggest this one!
0 people found this helpful
LovelySkin Customer
Verified Purchase
I first tried this as a sample and noticed results instantly which is why I've now ordered this product multiple times. My texture and tightness were improved not only with regular use but when applying under makeup in the morning. It gives a beautiful glow and healthy dewy look. It's really the biggest game changer I've stumbled across
0 people found this helpful
LovelySkin Customer
Verified Purchase
I have sensitive skin and this serum does not irritate at all.
0 people found this helpful
LovelySkin Customer
Verified Purchase
This serum has brightened and improved the texture of my skin. It does have a sting when you apply it.
0 people found this helpful
LovelySkin Customer
Verified Purchase
I love the Active Serum and use it in conjunction with the Active Peel. It keeps my skin smooth and exfoliated. Either of those would be beneficial but both together are absolutely amazing for skin resurfacing and clarity.
0 people found this helpful
HJ
Verified Purchase
I gave this to my 13 year old daughter. This product worked wonder clearing up pores on her T-zone area. It's pricey but will continue to buy it for her.
0 people found this helpful
LovelySkin Customer
Verified Purchase
I tend to have a bit more oily skin in the summer and more acne breakouts. This serum helps keep my skin clear. It is a bit spicy at first use.
0 people found this helpful
LovelySkin Customer
Verified Purchase
Love this for whenever I am getting a blemish. Within a day or two the blemish disappears. I just spot treat it when needed. If you use it everyday and all over your face it can dry your skin out but for spot treatment it is the best I have used. Will not be without it!
0 people found this helpful
selkie
I was surprised at how effective this product is. I follow it with another hydrating product. I also alternate it nightly with prescription Tretinoin cream that I use alone. I received this as a free full-size gift.
1 person found this helpful
AlohaElise
Verified Purchase
CLEARS SKIN+SO GENTLE LIKE WATER!
0 people found this helpful
CelticGoddess
Verified Purchase
This product has helped with my aging skin and acne issues. If I skip a day I can immediately tell the difference. Expensive, but worth every penny
0 people found this helpful
summerleeann
Verified Purchase
Used best with the pro heal serum and it is a must if you want to see a change in your skin!
0 people found this helpful
LovelySkin Customer
Verified Purchase
This serum definitely improved the texture of my skin and reduced breakouts! However, with consistent use, my skin’s sensitivity increased, and I became noticeably redder. I may use this occasionally to help improve my skin’s texture, but I will stick to gentler options for regular use.
0 people found this helpful
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20% Off Most Brands During Our Spring Renewal Sale + $27 SkinMedica Gift! 
