Obagi Nu-Derm Blend Fx is formulated to be used with your prescription tretinoin nightly for best results. You can use Blend Fx on its own without tretinoin, however it will take longer to see results this way.

Yes, Obagi Nu-Derm Blend Fx is formulated to be mixed with your prescription Retin-A, or you can use it with a non-prescription retinol like Obagi360 Retinol (http://www.lovelyskin.com/c/obagi360). We hope this information helps!

Even though alpha hydroxy acids are hydrophilic, and vitamin A is lipophilic, the base of both the Obagi Blend FX and RetinA is a cream which makes the two products compatible.

Due to recent changes in guidelines certain skin lightening products will no longer be available for purchase online. While this has not been discontinued by the manufacturer, it is available for purchase exclusively in person by authorized practices. We apologize for any inconvenience this may cause.

Hello. Thank you for your inquiry. The Obagi Nu-Derm Blend Fx #5 (Hydroquinone-Free Formula) was formulated as a face cream. However, you may use it on your hands, but face creams tend to be lighter than hand creams, and won't always quench the needs of your hand and may not provide the results you are looking for. I recommend the Revision Skincare Lumiquin as a hand cream that would help with Firming the hands and with concerns of Dark Spots.

Use this product in the evening mixed with your tretinoin/Retin-A. Measure ½ to 1 gram (approximately 1 to 2 pea-size drops) and apply evenly to the entire face, avoiding the eyelid area. Massage until completely absorbed. If you’re finding that the product isn’t spreading well even when mixing them together, you could try these additional tips: Use a Slightly Damp Face: Applying the mixture to slightly damp skin can help the products spread more easily and absorb better. Consider Adding a Lightweight Moisturizer: If the serum feels too thick after mixing, you could mix a small amount of moisturizer (lightweight, non-comedogenic) with the combination to help it spread more smoothly.